Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
Identifieur interne : 000F39 ( Main/Exploration ); précédent : 000F38; suivant : 000F40Intraoperative optical coherence tomography for assessing human lymph nodes for metastatic cancer
Auteurs : Ryan M. Nolan [États-Unis] ; Steven G. Adie [États-Unis] ; Marina Marjanovic [États-Unis] ; Eric J. Chaney [États-Unis] ; Fredrick A. South [États-Unis] ; Guillermo L. Monroy [États-Unis] ; Nathan D. Shemonski [États-Unis] ; Sarah J. Erickson-Bhatt [États-Unis] ; Ryan L. Shelton [États-Unis] ; Andrew J. Bower [États-Unis] ; Douglas G. Simpson [États-Unis] ; Kimberly A. Cradock [États-Unis] ; Z. George Liu [États-Unis] ; Partha S. Ray [États-Unis] ; Stephen A. Boppart [États-Unis]Source :
- BMC Cancer [ 1471-2407 ] ; 2016.
Abstract
Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of
We evaluated the use of optical coherence tomography (OCT), a high-resolution, real-time, label-free imaging modality for the intraoperative assessment of human LNs for metastatic disease in patients with breast cancer. We assessed the sensitivity and specificity of double-blinded trained readers who analyzed intraoperative OCT LN images for presence of metastatic disease, using co-registered post-operative histopathology as the gold standard.
Our results suggest that intraoperative OCT examination of LNs is an appropriate real-time, label-free, non-destructive alternative to frozen-section analysis, potentially offering faster interpretation and results to empower superior intraoperative decision-making.
Intraoperative OCT has strong potential to supplement current post-operative histopathology with real-time in situ assessment of LNs to preserve both non-cancerous nodes and their lymphatic vessels, and thus reduce the associated risks and complications from surgical disruption of lymphoid structures following biopsy.
Url:
DOI: 10.1186/s12885-016-2194-4
PubMed: 26907742
PubMed Central: 4763478
Affiliations:
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Le document en format XML
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<author><name sortKey="Erickson Bhatt, Sarah J" sort="Erickson Bhatt, Sarah J" uniqKey="Erickson Bhatt S" first="Sarah J." last="Erickson-Bhatt">Sarah J. Erickson-Bhatt</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana, IL 61801 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shelton, Ryan L" sort="Shelton, Ryan L" uniqKey="Shelton R" first="Ryan L." last="Shelton">Ryan L. Shelton</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana, IL 61801 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff8">PhotoniCare, Inc., Champaign, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>PhotoniCare, Inc., Champaign</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bower, Andrew J" sort="Bower, Andrew J" uniqKey="Bower A" first="Andrew J." last="Bower">Andrew J. Bower</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana, IL 61801 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Electrical and Computer Engineering, UIUC, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Electrical and Computer Engineering, UIUC, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simpson, Douglas G" sort="Simpson, Douglas G" uniqKey="Simpson D" first="Douglas G." last="Simpson">Douglas G. Simpson</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana, IL 61801 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff4">Department of Statistics, UIUC, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Statistics, UIUC, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cradock, Kimberly A" sort="Cradock, Kimberly A" uniqKey="Cradock K" first="Kimberly A." last="Cradock">Kimberly A. Cradock</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">Carle Foundation Hospital, Urbana, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Carle Foundation Hospital, Urbana</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Liu, Z George" sort="Liu, Z George" uniqKey="Liu Z" first="Z. George" last="Liu">Z. George Liu</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">Carle Foundation Hospital, Urbana, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Carle Foundation Hospital, Urbana</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ray, Partha S" sort="Ray, Partha S" uniqKey="Ray P" first="Partha S." last="Ray">Partha S. Ray</name>
<affiliation wicri:level="2"><nlm:aff id="Aff5">Carle Foundation Hospital, Urbana, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Carle Foundation Hospital, Urbana</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff6">Department of Surgery, University of Illinois College of Medicine at Urbana-Champaign and Carle Cancer Center, Urbana, IL USA</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Surgery, University of Illinois College of Medicine at Urbana-Champaign and Carle Cancer Center, Urbana</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Boppart, Stephen A" sort="Boppart, Stephen A" uniqKey="Boppart S" first="Stephen A." last="Boppart">Stephen A. Boppart</name>
<affiliation wicri:level="2"><nlm:aff id="Aff1">Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana, IL 61801 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign (UIUC), 405 N. Mathews Ave., Urbana</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Electrical and Computer Engineering, UIUC, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Electrical and Computer Engineering, UIUC, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff3">Department of Bioengineering, UIUC, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Bioengineering, UIUC, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff7">Department of Internal Medicine, UIUC, Illinois, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine, UIUC, Illinois</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Cancer</title>
<idno type="eISSN">1471-2407</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Evaluation of lymph node (LN) status is an important factor for detecting metastasis and thereby staging breast cancer. Currently utilized clinical techniques involve the surgical disruption and resection of lymphatic structure, whether nodes or axillary contents, for histological examination. While reasonably effective at detection of <italic>macrometastasis</italic>
, the majority of the resected lymph nodes are histologically negative. Improvements need to be made to better detect <italic>micrometastasis</italic>
, minimize or eliminate lymphatic disruption complications, and provide immediate and accurate intraoperative feedback for in vivo cancer staging to better guide surgery.</p>
</sec>
<sec><title>Methods</title>
<p>We evaluated the use of optical coherence tomography (OCT), a high-resolution, real-time, label-free imaging modality for the intraoperative assessment of human LNs for metastatic disease in patients with breast cancer. We assessed the sensitivity and specificity of double-blinded trained readers who analyzed intraoperative OCT LN images for presence of metastatic disease, using co-registered post-operative histopathology as the gold standard.</p>
</sec>
<sec><title>Results</title>
<p>Our results suggest that intraoperative OCT examination of LNs is an appropriate real-time, label-free, non-destructive alternative to frozen-section analysis, potentially offering faster interpretation and results to empower superior intraoperative decision-making.</p>
</sec>
<sec><title>Conclusions</title>
<p>Intraoperative OCT has strong potential to supplement current post-operative histopathology with real-time in situ assessment of LNs to preserve both non-cancerous nodes and their lymphatic vessels, and thus reduce the associated risks and complications from surgical disruption of lymphoid structures following biopsy.</p>
</sec>
</div>
</front>
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</analytic>
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</biblStruct>
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<author><name sortKey="Singletary, Kw" uniqKey="Singletary K">KW Singletary</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, W" uniqKey="Luo W">W Luo</name>
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</analytic>
</biblStruct>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pepe, Ms" uniqKey="Pepe M">MS Pepe</name>
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</analytic>
</biblStruct>
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<author><name sortKey="Boppart, Sa" uniqKey="Boppart S">SA Boppart</name>
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</analytic>
</biblStruct>
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</biblStruct>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adie, Sg" uniqKey="Adie S">SG Adie</name>
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</biblStruct>
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</analytic>
</biblStruct>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zysk, Am" uniqKey="Zysk A">AM Zysk</name>
</author>
<author><name sortKey="Nguyen, Ft" uniqKey="Nguyen F">FT Nguyen</name>
</author>
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<author><name sortKey="Kotynek, Jg" uniqKey="Kotynek J">JG Kotynek</name>
</author>
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</author>
<author><name sortKey="Bellafiore, Fj" uniqKey="Bellafiore F">FJ Bellafiore</name>
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</analytic>
</biblStruct>
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</author>
<author><name sortKey="Mclaughlin, Ra" uniqKey="Mclaughlin R">RA McLaughlin</name>
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</author>
<author><name sortKey="Kirk, Rw" uniqKey="Kirk R">RW Kirk</name>
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</analytic>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Illinois</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Nolan, Ryan M" sort="Nolan, Ryan M" uniqKey="Nolan R" first="Ryan M." last="Nolan">Ryan M. Nolan</name>
</region>
<name sortKey="Adie, Steven G" sort="Adie, Steven G" uniqKey="Adie S" first="Steven G." last="Adie">Steven G. Adie</name>
<name sortKey="Adie, Steven G" sort="Adie, Steven G" uniqKey="Adie S" first="Steven G." last="Adie">Steven G. Adie</name>
<name sortKey="Boppart, Stephen A" sort="Boppart, Stephen A" uniqKey="Boppart S" first="Stephen A." last="Boppart">Stephen A. Boppart</name>
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<name sortKey="Boppart, Stephen A" sort="Boppart, Stephen A" uniqKey="Boppart S" first="Stephen A." last="Boppart">Stephen A. Boppart</name>
<name sortKey="Boppart, Stephen A" sort="Boppart, Stephen A" uniqKey="Boppart S" first="Stephen A." last="Boppart">Stephen A. Boppart</name>
<name sortKey="Bower, Andrew J" sort="Bower, Andrew J" uniqKey="Bower A" first="Andrew J." last="Bower">Andrew J. Bower</name>
<name sortKey="Bower, Andrew J" sort="Bower, Andrew J" uniqKey="Bower A" first="Andrew J." last="Bower">Andrew J. Bower</name>
<name sortKey="Chaney, Eric J" sort="Chaney, Eric J" uniqKey="Chaney E" first="Eric J." last="Chaney">Eric J. Chaney</name>
<name sortKey="Cradock, Kimberly A" sort="Cradock, Kimberly A" uniqKey="Cradock K" first="Kimberly A." last="Cradock">Kimberly A. Cradock</name>
<name sortKey="Erickson Bhatt, Sarah J" sort="Erickson Bhatt, Sarah J" uniqKey="Erickson Bhatt S" first="Sarah J." last="Erickson-Bhatt">Sarah J. Erickson-Bhatt</name>
<name sortKey="Liu, Z George" sort="Liu, Z George" uniqKey="Liu Z" first="Z. George" last="Liu">Z. George Liu</name>
<name sortKey="Marjanovic, Marina" sort="Marjanovic, Marina" uniqKey="Marjanovic M" first="Marina" last="Marjanovic">Marina Marjanovic</name>
<name sortKey="Monroy, Guillermo L" sort="Monroy, Guillermo L" uniqKey="Monroy G" first="Guillermo L." last="Monroy">Guillermo L. Monroy</name>
<name sortKey="Monroy, Guillermo L" sort="Monroy, Guillermo L" uniqKey="Monroy G" first="Guillermo L." last="Monroy">Guillermo L. Monroy</name>
<name sortKey="Nolan, Ryan M" sort="Nolan, Ryan M" uniqKey="Nolan R" first="Ryan M." last="Nolan">Ryan M. Nolan</name>
<name sortKey="Ray, Partha S" sort="Ray, Partha S" uniqKey="Ray P" first="Partha S." last="Ray">Partha S. Ray</name>
<name sortKey="Ray, Partha S" sort="Ray, Partha S" uniqKey="Ray P" first="Partha S." last="Ray">Partha S. Ray</name>
<name sortKey="Shelton, Ryan L" sort="Shelton, Ryan L" uniqKey="Shelton R" first="Ryan L." last="Shelton">Ryan L. Shelton</name>
<name sortKey="Shelton, Ryan L" sort="Shelton, Ryan L" uniqKey="Shelton R" first="Ryan L." last="Shelton">Ryan L. Shelton</name>
<name sortKey="Shemonski, Nathan D" sort="Shemonski, Nathan D" uniqKey="Shemonski N" first="Nathan D." last="Shemonski">Nathan D. Shemonski</name>
<name sortKey="Shemonski, Nathan D" sort="Shemonski, Nathan D" uniqKey="Shemonski N" first="Nathan D." last="Shemonski">Nathan D. Shemonski</name>
<name sortKey="Shemonski, Nathan D" sort="Shemonski, Nathan D" uniqKey="Shemonski N" first="Nathan D." last="Shemonski">Nathan D. Shemonski</name>
<name sortKey="Simpson, Douglas G" sort="Simpson, Douglas G" uniqKey="Simpson D" first="Douglas G." last="Simpson">Douglas G. Simpson</name>
<name sortKey="Simpson, Douglas G" sort="Simpson, Douglas G" uniqKey="Simpson D" first="Douglas G." last="Simpson">Douglas G. Simpson</name>
<name sortKey="South, Fredrick A" sort="South, Fredrick A" uniqKey="South F" first="Fredrick A." last="South">Fredrick A. South</name>
<name sortKey="South, Fredrick A" sort="South, Fredrick A" uniqKey="South F" first="Fredrick A." last="South">Fredrick A. South</name>
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</tree>
</affiliations>
</record>
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